Enzyme-HOF Hybrid Particles Composite Hydrogel Dressing for Diabetic Wound Healing

Diabetic wounds (DWs) face challenges from persistent hyperglycemia, bacterial infection, and abnormal pH levels, which collectively impede healing. Traditional treatments, such as antibiotics and debridement, often show limitations such as drug resistance, pain, or high cost. To address this issue, a hybrid particle is developed based on in situ encapsulating glucose oxidase (GOx) in hydrogen-bonded organic framework HOF-101, enabling enzyme immobilization under mild conditions while preserving catalytic activity. The particle is formed through hydrogen bonding-triggered self-assembly and polydopamine coating and subsequently incorporated into a dual-network hydrogel matrix. The resulting composite hydrogel achieves efficient pH reduction and H₂O₂ generation by consuming glucose, while exhibiting tunable photothermal responses under near-infrared (NIR) irradiation, thus enabling local microenvironment modulation and synergistic antibacterial effects. In addition, the hydrogel demonstrates favorable mechanical properties and biocompatibility. These results suggest its great potential for application in DW healing.