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Triple Homicide With Thallium Sulfate: Microscopic Postmortem Findings at Different Survival Time
Stefano Tambuzzi1, Guendalina Gentile, Enrico Muccino
1Laboratory of Forensic Histopathology and Forensic Microbiology, Institute of Forensic Medicine and Insurance of the University of Milan, Milan, Italy.
The American Journal of Forensic Medicine and Pathology
|October 30, 2025
Summary
Homicidal thallium poisoning is rare, with unclear biological and histologic signs. This study details microscopic findings in a unique forensic case, revealing short- and medium-term effects of thallium toxicity.
Area of Science:
- Forensic Toxicology
- Histopathology
- Toxicology
Background:
- Thallium was a common rat poison but is now banned due to high toxicity.
- Homicidal thallium poisoning is rare, with limited understanding of its biological and histological manifestations.
- Existing literature lacks detailed information on the short- and medium-term effects of thallium poisoning.
Purpose of the Study:
- To investigate and document the microscopic evidence of homicidal thallium poisoning.
- To elucidate the gastrointestinal and systemic effects of thallium toxicity.
- To enhance the forensic understanding of thallium-induced lesions.
Main Methods:
- Analysis of a unique forensic case involving three victims of homicidal thallium poisoning with varying survival times.
- Microscopic examination of viscera to identify histological lesions.
- Documentation of findings with comprehensive iconography.
Main Results:
- Detailed microscopic pictures of thallium poisoning, including gastrointestinal transit signs and systemic effects.
- Identification of short- and medium-term histological changes induced by thallium.
- Evidence supporting the cause of death related to thallium toxicity in the affected organs.
Conclusions:
- The study provides crucial microscopic evidence for identifying thallium poisoning in forensic investigations.
- It expands knowledge on the currently unknown short- and medium-term effects of thallium toxicity.
- The findings aim to enrich the forensic literature on this rare but fatal poisoning.

