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  11. Investigation Of Association Between Serum C-reactive Protein Concentrations And Proteinuria In Dogs.

Investigation of association between serum C-reactive protein concentrations and proteinuria in dogs.

E Ruane1, M M A Rodgers1, C H Z Hare1

  • 1Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

The Journal of Small Animal Practice
|October 30, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Serum C-reactive protein concentrations and specific diseases are linked to proteinuria in dogs. Chronic enteropathy showed decreased odds of proteinuria, while chronic hepatitis and pancreatitis showed increased odds.

Area of Science:

  • Veterinary Medicine
  • Canine Health
  • Biomarkers

Background:

  • Proteinuria, an indicator of kidney damage, can be influenced by systemic conditions.
  • Serum C-reactive protein (CRP) is a marker of inflammation.
  • Understanding associations between CRP, diseases, and proteinuria is crucial for canine health.

Purpose of the Study:

  • To investigate the relationship between serum C-reactive protein (CRP) concentrations, specific canine diseases, and proteinuria.
  • To determine if CRP levels and certain diseases are independent predictors of proteinuria in dogs without pre-existing renal, pre-renal, or post-renal causes.

Main Methods:

  • Retrospective study including dogs with measured urine protein:creatinine ratio (UPC) and serum CRP.
  • Dogs with known causes of pathological proteinuria were excluded.

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  • Multivariable logistic regression was used to analyze associations between proteinuria, CRP, and specific diseases.

    • Main Results:

    • Proteinuria (UPC >0.2) was less prevalent in dogs with chronic enteropathy.
    • Proteinuria was more prevalent in dogs with chronic hepatitis and tended to be more prevalent in dogs with pancreatitis.
    • Elevated serum CRP concentrations were independently associated with increased odds of proteinuria (OR=1.031).

    Conclusions:

    • Systemic inflammation, indicated by elevated CRP, may be associated with proteinuria in dogs.
    • Chronic enteropathy is associated with decreased odds of proteinuria.
    • Further research is needed to establish a causal link and evaluate the effect of resolving underlying conditions on proteinuria.