Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies

Area of Science:

• Cancer neuroscience
• Neuro-oncology
• Tumor microenvironment (TME) research

Background:

• The nervous system dynamically interacts with tumors, influencing cancer hallmarks like proliferation and metastasis.
• Tumor microenvironment (TME) is heavily influenced by bidirectional neural signaling.
• Neural ablation studies show context-dependent effects, highlighting the need for targeted approaches.

Purpose of the Study:

• To review recent advancements in cancer neuroscience.
• To propose therapeutic frameworks targeting neural-TME interactions.
• To explore interdisciplinary strategies integrating neuroscience and oncology.

Main Methods:

• Review of preclinical and clinical data on neural-targeted therapies.
• Exploration of drug repurposing (e.g., beta-blockers, antipsychotics, antidepressants).
• Investigation of nanotechnology-enabled targeted delivery systems.

Main Results:

• Neural-TME interactions significantly modulate cancer progression.
• Nerve-type-specific and context-dependent therapeutic strategies are crucial.
• Neural-targeted therapies show potential in improving precision and overcoming drug resistance.

Conclusions:

• Cancer neuroscience provides a framework for understanding and targeting neural-tumor crosstalk.
• Interdisciplinary approaches integrating neuroscience and oncology are key to advancing cancer therapeutics.
• Targeting the neuro-innervated TME offers a promising avenue for improved patient care and treatment outcomes.