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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
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Brain Network Signature of Autoscopic Phenomena in Humans
Siyi Wang1,2, Lei Qi1,2,3, Xinqi Huang1,2
1Department of Neurology, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing, China.
CNS Neuroscience & Therapeutics
|October 30, 2025
Summary
This study mapped the brain network for autoscopic phenomena (AP), revealing its connections to specific brain regions and neurochemical/electrophysiological markers. These findings offer insights into the neural basis of bodily self-consciousness.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Autoscopic phenomena (AP) are observed in epilepsy and psychiatric disorders.
- Understanding the neural network of AP is crucial for diagnosis and treatment.
Purpose of the Study:
- To map the brain network associated with autoscopic phenomena (AP).
- To characterize the multimodal signatures of the AP network.
Main Methods:
- Lesion network mapping using the human connectome dataset (n=1000).
- Analysis of 25 cases with AP from focal brain lesions and direct electrical stimulation (DES).
- Exploration of correlations with cortical development, neurotransmitters, and electrophysiological rhythms.
Main Results:
- A common AP network was identified, involving bilateral angular gyrus, posterior medial cortex, intraparietal sulcus, cuneus, fusiform, and insula.
- Bilateral thalamic pulvinar identified as subcortical hubs.
- Negative correlation with cortical developmental/evolutionary expansions; positive correlation with norepinephrine transporter density and alpha frequency band power.
Conclusions:
- A common brain AP network and its multimodal signatures were identified.
- Findings clarify network mechanisms of AP and offer insights into bodily self-consciousness.
