Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrative Analysis Reveals Conserved R-Loop Features in Mouse Embryonic Stem Cells.

Epigenomes·2026

Same author

Chicken Embryo Extract Remodeling of Extracellular Matrix Sustains Self-Renewal and Differentiation for Scaffold-Free Cell Sheet Formation.

Biomaterials research·2026

Same author

Stem Cell R&D in Korea: Yesterday, Today, and Tomorrow - A Paradigm Shift from Therapeutics to Bio-Platforms.

International journal of stem cells·2025

Same author

Effect of Extracellular Matrix Derived from Porcine Tissue on Stemness of Porcine Spermatogonial Stem Cells.

International journal of molecular sciences·2025

Same author

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.

International journal of molecular sciences·2025

Same author

Regulatory Landscapes of Muscle Satellite Cells: From Mechanism to Application.

International journal of stem cells·2025

Search research articles

Related Experiment Video

Updated: Jan 12, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Stem Cell-Derived Embryo Models: Potential Platforms for Investigating Early Development and Embryotoxicity.

Yeji Lee¹, Jeong Tae Do¹

¹School of Advanced Biotechnology, Konkuk University, Seoul, Korea.

International Journal of Stem Cells

|October 30, 2025

Summary

Stem cell-derived embryo models (SCDEMs) offer a novel in vitro approach to study early mammalian development and implantation. These synthetic embryos hold promise for advancing developmental biology and embryotoxicity testing.

Keywords:

Developmental toxicity Embryonic development Environmental pollution Stem cell-derived embryo model Toxicology

More Related Videos

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Related Experiment Videos

Last Updated: Jan 12, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Area of Science:

Developmental Biology
Stem Cell Research
Reproductive Toxicology

Background:

Conventional in vivo methods face challenges in investigating early embryonic development, implantation, and post-implantation stages.
Stem cell-derived embryo models (SCDEMs) recapitulate key pre- and peri-implantation developmental processes in vitro.
These models provide a unique platform for studying complex early embryogenesis dynamics.

Purpose of the Study:

To provide a comprehensive overview of SCDEMs, including generation methodologies and stem cell types used.
To evaluate the recapitulation of key developmental processes by SCDEMs.
To assess the utility and limitations of SCDEMs in embryotoxicity studies and suggest future research directions.

Main Methods:

Review of methodologies for generating synthetic embryos from various stem cell sources.
Analysis of studies demonstrating the recapitulation of pre- and post-implantation mammalian development by SCDEMs.
Evaluation of the strengths and limitations of SCDEMs in the context of embryotoxicity testing.

Main Results:

SCDEMs closely recapitulate critical in vivo developmental events, offering insights into morphological dynamics and underlying mechanisms.
Synthetic embryos serve as valuable tools for studying environmental toxicity, overcoming limitations of in vivo studies.
The review details diverse stem cell types and generation techniques for creating these advanced models.

Conclusions:

SCDEMs significantly advance the study of early mammalian developmental biology and embryogenesis.
These models offer a powerful platform for both fundamental research and applied toxicology.
Future research strategies should focus on refining SCDEMs and expanding their application in developmental and toxicological studies.