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Infant Auditory Processing and Event-related Brain Oscillations
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Newborn Auditory Brainstem Response and Sudden Infant Death Syndrome.

Sarah E Maylott1, Guangyu Zeng2, Tiffany S Leung3

  • 1Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.

Journal of Neuroscience Research
|October 30, 2025
PubMed
Summary

Newborns who died of sudden infant death syndrome (SIDS) were more likely to have abnormal auditory brainstem responses (ABRs). ABR screening may help identify infants at risk for SIDS, potentially enabling early interventions.

Keywords:
brainstem auditory evoked potentialbrainstem auditory evoked responsehealthinfancymortalityneonate

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Area of Science:

  • Neuroscience
  • Pediatrics
  • Sleep Medicine

Background:

  • Sudden infant death syndrome (SIDS) is the unexplained death of infants under one year old.
  • Brainstem abnormalities affecting breathing and arousal during sleep are suspected in SIDS.
  • Auditory brainstem response (ABR) noninvasively assesses brainstem function in response to sound.

Purpose of the Study:

  • To investigate if neonatal auditory brainstem response (ABR) anomalies predict SIDS.
  • To compare ABR measures in newborns who later died of SIDS with a normative sample.

Main Methods:

  • Utilized integrated secondary datasets of archived neonatal ABR results from Florida.
  • Compared ABRs of 11 infants who died of SIDS with 198,990 non-SIDS infants.
  • Analyzed ABR latencies, specifically the trough following peak V in the left ear.

Main Results:

  • Infants who died of SIDS showed a higher likelihood of abnormal ABRs as newborns compared to non-SIDS infants.
  • A potential finding of shorter latencies in the left ear for SIDS infants was not replicated in expert-rated data.
  • The study suggests abnormal neonatal ABRs may be associated with SIDS risk.

Conclusions:

  • Neonatal ABR screening could potentially identify infants at higher risk for SIDS.
  • Early identification may allow for increased monitoring and timely interventions.
  • Further research is needed to confirm the predictive value of ABR for SIDS.