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Case Study of an Unusual Intracranial Mesenchymal Neoplasm
Camille Carlisle1, Alexandra Lesko2, Vassil Kaimaktchiev3
1College of Osteopathic Medicine of the Pacific Northwest, Western University of Health Sciences, Lebanon, Oregon, USA.
Neurosurgery Practice
|October 30, 2025
Summary
A rare brain tumor in a multiple sclerosis patient was successfully removed using a specialized trans-sylvian surgical approach. This technique offers a feasible option for accessing challenging posterior insula lesions.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Neuroimaging
Background:
- A 51-year-old woman with multiple sclerosis (MS) presented with a slowly growing, enhancing lesion in the left posterior insula, distinct from MS plaques.
- Histopathology identified the lesion as a low-grade mesenchymal neoplasm, not elsewhere classified, highlighting the need to expand the classification of central nervous system tumors.

