Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.7K
T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

772
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
772
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.9K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pleural fluid C-C motif chemokine ligand 2 as a diagnostic biomarker for malignant pleural effusion.

Journal of thoracic disease·2026
Same author

Immunodynamic changes in a mouse model of malignant pleural effusion.

Laboratory animal research·2026
Same author

Interleukin 32 as a Potential Marker for Diagnosis of Tuberculous Pleural Effusion.

Microbiology spectrum·2022
Same author

Single-cell analysis of diverse immune phenotypes in malignant pleural effusion.

Nature communications·2021
Same author

TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T<sub>H</sub>1/T<sub>H</sub>17 Cell Response.

Journal of immunology (Baltimore, Md. : 1950)·2020
Same author

Prognostic value of a new score using serum alkaline phosphatase and pleural effusion lactate dehydrogenase for patients with malignant pleural effusion.

Thoracic cancer·2019

Related Experiment Video

Updated: Jan 12, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

9.1K

T-cell subsets in Pneumocystis pneumonia.

Yuxi Chen1, Hengmo Rong2, Ting Li2

  • 1Department of Critical Care Medicine Zhongnan Hospital of Wuhan University Wuhan China.

Clinical & Translational Immunology
|October 30, 2025
PubMed
Summary

T cells are crucial for fighting Pneumocystis pneumonia (PCP), a fungal infection common in immunocompromised individuals. Understanding specific T cell roles may lead to new anti-PCP treatments.

Keywords:
Adaptive immune responseCD4+ T cellsCD8+ T cellsPneumocystis pneumonia

More Related Videos

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
10:29

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

11.0K
Experimental Model to Evaluate Resolution of Pneumonia
09:49

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

1.8K

Related Experiment Videos

Last Updated: Jan 12, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

9.1K
Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
10:29

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

11.0K
Experimental Model to Evaluate Resolution of Pneumonia
09:49

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

1.8K

Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Pneumocystis pneumonia (PCP) is a significant fungal infection in immunocompromised populations.
  • T cells, including CD4+ and CD8+ subsets, are vital for host defense against Pneumocystis.
  • The precise T cell responses needed for effective adaptive immunity against PCP are not fully understood.

Purpose of the Study:

  • To review the roles of distinct T cell subsets in host defense against Pneumocystis.
  • To explore how understanding T cell functions can inform anti-PCP treatment strategies.

Main Methods:

  • Literature review focusing on T cell subsets and their functions in Pneumocystis immunity.
  • Analysis of cytokine profiles and immune cell interactions in PCP pathogenesis.

Main Results:

  • Specific CD4+ and CD8+ T cell subsets influence fungal burden and disease severity through cytokines and immune cell interactions.
  • The integrated functions of T cell subsets are critical for adaptive immune responses to Pneumocystis.

Conclusions:

  • A comprehensive understanding of T cell subset functions in Pneumocystis immunity is essential.
  • Insights into T cell responses could facilitate the development of novel anti-PCP therapies.