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Male Breast Cancer Brain Metastases: Genetic Profiles and Radiosurgery Outcomes
Yusuke S Hori1, Paul M Harary1, Aroosa Zamarud1
1Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Neurosurgery Practice
|October 30, 2025
Summary
This study explored genetic alterations in male breast cancer (MBC) with brain metastases (BM) and found stereotactic radiosurgery (SRS) to be safe and effective. Genetic profiling revealed disease heterogeneity, suggesting potential for personalized treatment strategies in MBC BM.
Area of Science:
- Oncology
- Genetics
- Neurosurgery
Background:
- Male breast cancer (MBC) with brain metastases (BM) is rare, with limited data on its genetic characteristics.
- Previous reports on stereotactic radiosurgery (SRS) for MBC BM are scarce, with only one case documented.
Purpose of the Study:
- To investigate the genetic alterations associated with BM in male breast cancer patients.
- To evaluate the safety and efficacy of SRS in treating MBC BM.
Main Methods:
- Retrospective review of four male patients with 20 MBC BMs treated with SRS.
- Response evaluation using RECIST criteria and local progression (LP) assessment.
- Kaplan-Meier method for estimating LP incidence rate.
Main Results:
- Median overall survival was 16.3 months.
- Three patients had estrogen receptor-positive disease, one had triple-negative disease.
- Notable pathogenic alterations identified in AURKA, BRCA1, BRCA2, CCND1, CHEK2, ERBB2, FLT3, RAF1, and SPINK1.
- Excellent local control rates at 6 and 12 months (100%) with SRS, with only one lesion progressing.
Conclusions:
- This study presents the first genetic profiling of MBC with BM.
- Genetic alterations and receptor status suggest heterogeneity in MBC BM.
- SRS demonstrates excellent outcomes for MBC BM, warranting further investigation.
