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Efficacy and Safety of Tofacitinib in Paediatric Alopecia Aerata - A Prospective Observational Study
Farah Khan1, Neha Shukla2, Chandrashekhar Jaiswal3
1Department of Dermatology, Venereology and Leprosy, AIIMS, Bhopal, Madhya Pradesh, India.
Background:
Alopecia areata (AA) is an autoimmune condition marked by non-scarring hair loss.
Materials And Method:
In this prospective observational study, we enrolled 50 pediatric patients with moderate-to-severe alopecia areata. Participants received oral tofacitinib for 24 weeks. Clinical efficacy was assessed using the Severity of Alopecia Tool (SALT) score. Secondary outcomes included time to hair regrowth, patient/parent satisfaction, and Paediatric Quality of Life Inventory (PedsQL) scores.
Result:
Forty-five participants completed the 24-week study. A significant decrease in SALT score from baseline (mean 66.2 ± 8.1) to week 24 (mean 25.7 ± 9.2) was observed (P < 0.001). Complete or near-complete hair regrowth was achieved in 42.2% of patients, with partial regrowth in 37.8%.
Conclusion:
Tofacitinib demonstrated a favorable risk-benefit profile for treating moderate-to-severe pediatric alopecia areata over 24 weeks. These findings support the potential of JAK inhibitors as a therapeutic option in children with recalcitrant disease, although long-term safety and relapse rates warrant further investigation.
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