Related Experiment Video
Updated: Jan 12, 2026
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
Published on: August 20, 2021
In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation
Rajendran Senthilnathan1, Neelam Das2, Atika Ismail3
1Professor, Department of Oral and Maxillofacial Surgery, Sree Balaji Dental College and Hospital, Chennai, Tamil Nadu, India.
Objective:
This study evaluated the ability of Fibro-Gide® and Mucoderm® collagen matrices to stimulate fibroblast proliferation.
Materials And Methods:
The study tested two collagen matrices, Mucoderm® and Fibro-Gide®, on human gingival fibroblasts. Surface roughness, cell viability, and collagen quantities were measured using profilometers and ELISA.
Results:
Fibro-Gide® outperformed Mucoderm® in terms of surface roughness (2.75 μm) and cell survival, while ELISA findings showed a greater collagen type and a higher optical density (0.920 OD).
Conclusion:
Fibro-Gide® showed better fibroblast proliferation and extracellular matrix production, indicating promise for tissue regeneration and remodeling in periodontal and peri-implant applications, while Mucoderm® remains viable.
