Related Experiment Video
Updated: Jan 12, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Study of Serum Creatinine Level in Essential Hypertension: An Observational Study
Swati Pandit Sarnaik1,2, Jijaba M Shirke3, Ranjit A Deshmukh4
1Ph.D Scholer, Department of Rognidan Vikrutivigyan, Dr. D. Y. Patil College of Ayurved & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemeed to be University), Pune, Maharashtra, India.
Introduction:
Hypertension-a major global health concern affecting over 1.13 billion individuals-is a key contributor to cardiovascular, cerebrovascular, and renal diseases.
Materials And Methods:
A cross-sectional study was conducted at P.R. Pote Hospital, Amravati, including 70 hypertensive patients and 50 normotensive controls aged 30-50 years. After a 12-hour fast, blood samples were collected, and serum creatinine levels were estimated using a semi-auto analyzer. Statistical analysis involved t-tests, Mann-Whitney U tests, and correlation studies.
Results:
Hypertensive patients had significantly higher mean serum creatinine levels (0.88 mg/dL) than normotensive individuals (0.77 mg/dL). Serum creatinine positively correlated with both systolic and diastolic blood pressure. Moderate positive correlations were also observed with cholesterol, LDL, and VLDL, while HDL showed a weak negative correlation.
Discussion:
These findings indicate a clear association between hypertension and renal function decline. The correlations with lipid profiles further support existing evidence of metabolic involvement.
Conclusion:
Regular monitoring of serum creatinine in hypertensive patients is crucial for early detection of renal impairment and prevention of chronic kidney disease progression.
Related Concept Videos
Serum Studies: Renal Function Tests
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Hypertension III: Clinical Manifestations and Diagnostic Studies
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

