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Updated: Jan 12, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontal Diseases and Host Modulation Therapies.

Abdulaziz Alsakr1

  • 1Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia.

Journal of Pharmacy & Bioallied Sciences
|October 30, 2025
PubMed
Summary

Host modulation therapy (HMT) offers a promising approach to treating periodontal disease by targeting the host

Area of Science:

  • Periodontology
  • Microbiology
  • Immunology

Background:

  • Periodontal diseases are initiated by bacterial pathogens, with the host's response playing a critical role.
  • Current treatments focus on bacterial reduction, but host-directed therapies offer a complementary strategy.
  • Host modulation therapy (HMT) aims to manage the host's inflammatory and immune responses.

Purpose of the Study:

  • To review the current landscape of host modulation in treating and preventing periodontal diseases.
  • To evaluate the efficacy of various HMT approaches, including pharmaceutical agents, probiotics, and immunomodulatory methods.
  • To highlight the potential of HMT in improving periodontal treatment outcomes and preventing tissue damage.

Main Methods:

  • Systematic review of studies evaluating host modulation strategies for periodontal diseases.
Keywords:
Host modulating agentsNSAIDTNFperiodontal diseases

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  • Analysis of research on pharmaceutical agents, probiotics, and immunomodulatory interventions.
  • Inclusion of studies focusing on reducing bacterial biofilm and managing host response.

    • Main Results:

    • HMT, alongside conventional periodontal therapy, shows potential in improving disease management and reducing tissue damage.
    • Strategies include reducing bacterial biofilm, managing inflammation, restoring microbiome balance, and modulating immune responses.
    • Pharmaceuticals, probiotics, and immunomodulatory agents are key components of HMT.

    Conclusions:

    • Host modulation therapy presents a promising avenue for enhanced periodontal disease treatment and prevention.
    • By targeting host response, HMT can complement traditional therapies and improve clinical outcomes.
    • Further research into specific HMT agents and their mechanisms is warranted.