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Updated: Jan 12, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Impact of Intermittent Fasting on Glycemic Control in Type 2 Diabetes: An Original Research
Maarya Mohammed Siddiqi1, Muneza Mariam Farhan1, Moosa Mohammed Siddiqi1
1MBBS, Shadan Institute of Medical Sciences, Hyderabad, Telangana, India.
Background:
"Type 2 diabetes (T2D)" requires effective glycemic control to prevent complications. "Intermittent fasting (IF)" is a potential lifestyle intervention that may improve glycemic outcomes, though evidence is still evolving.
Objective:
This study evaluated the impact of IF on glycemic control and metabolic health in T2D.
Methods:
One hundred adults with T2D were randomly assigned to an IF group (50 following an 8-h eating window) or a control group, non-dietary advice. The primary outcomes were glycated Hemoglobin A1c (HbA1C), and fasting glucose; secondary outcomes included "body mass index (BMI)" or waist circumference, a surrogate marker of central obesity, and insulin resistance by homeostasis model assessment-insulin resistance test (HOMA-IR). We performed hypothesis tests to test for changes within and between groups.
Results:
The IF group showed a significant drop in HbA1c (8.2 to 7.4%, P < 0.001), fasting glucose, BMI, waist circumference, and insulin resistance index by HOMA-IR (3.8 to 3; P < 0.01).
Conclusion:
IF significantly improved glycemic control, body composition, and insulin sensitivity in T2D patients, indicating its potential as a non-pharmacological management strategy. Further research is recommended to explore long-term effects and IF regimen variations.
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