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Related Concept Videos

Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

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Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
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Related Experiment Video

Updated: Jan 12, 2026

Scanning Electron Microscopic Evaluation of Surface Defects of Remover Retreatment File After Single and Multiple Uses
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Success Rates in Single-Visit Versus Multiple-Visit Root Canal Treatments: A Prospective Study.

Diganta Kumar Borah1, Ninad Upendra Shah2, Shamini Pawar3

  • 1Department of Conservative Dentistry and Endodontics, Regional Dental College, Guwahati, Assam, India.

Journal of Pharmacy & Bioallied Sciences
|October 30, 2025
PubMed
Summary
This summary is machine-generated.

Single-visit root canal treatment (RCT) shows comparable success rates to multiple-visit RCT. While initial pain is slightly higher, single-visit RCT offers greater patient satisfaction due to convenience.

Keywords:
Multiple-visitpatient satisfactionpost-operative painsingle-visitsuccess rate

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Area of Science:

  • Endodontics
  • Dental Public Health

Background:

  • Root canal treatment (RCT) is crucial for managing dental pulp infections.
  • Debate exists regarding the comparative efficacy of single-visit versus multiple-visit RCT.
  • Key comparison points include success rates, post-operative pain, and patient satisfaction.

Purpose of the Study:

  • To compare the clinical success rates of single-visit versus multiple-visit RCT.
  • To evaluate and contrast post-operative complications and patient satisfaction between the two RCT approaches.
  • To provide evidence-based insights for clinical decision-making in endodontic therapy.

Main Methods:

  • A randomized clinical trial involving 100 patients requiring RCT.
  • Patients were allocated to either single-visit (n=50) or multiple-visit (n=50) treatment groups.
  • Outcomes assessed included 12-month clinical and radiographic success, Visual Analog Scale (VAS) pain scores, and patient satisfaction questionnaires.

Main Results:

  • No statistically significant difference in 12-month success rates between single-visit (85%) and multiple-visit (87%) RCT (P=0.67).
  • Single-visit RCT showed slightly higher initial post-operative pain at 24 hours (VAS 4.5 vs. 3.0, P=0.03), with similar levels by one week.
  • Patient satisfaction was notably higher in the single-visit group (92%) compared to the multiple-visit group (85%).

Conclusions:

  • Both single-visit and multiple-visit RCTs demonstrate comparable long-term success rates.
  • Single-visit RCT offers enhanced patient satisfaction due to convenience, despite potentially higher initial discomfort.
  • Treatment choice should be individualized, considering patient factors and preferences.