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PCNA and MCM 2 in Odontogenic Tumors: An Immunnohistological Study
Sarat K Nayak1, Mitali Dash2, Anshuman Shetty3
1Department of Oral and Maxillofacial Pathology and Microbiology, S. C. B. Dental College, Cuttack, Odisha, India.
Background:
The proliferative potential of odontogenic tumors is an important factor in understanding their aggressive behavior. "Proliferating Cell Nuclear Antigen (PCNA)" is a functional and structural component of DNA replication factor, while "Minichromosome Maintenance Protein 2 (MCM2)", from the MCM family, mediates cell proliferation as well as progression through to S-phase. Here, we aimed to evaluate the expression of PCNA and MCM2 in odontogenic tumors with a special emphasis on ameloblastomas and "keratocystic odontogenic tumors (KCOTs)".
Materials And Methods:
Immunohistochemical staining for PCNA and MCM2 was performed in tissue samples of ameloblastoma and KCOT. The expression levels were studied.
Results:
Both PCNA and MCM2 were overexpressed significantly higher in ameloblastomas compared to KCOT. A strong correlation was also noted between increased MCM2 expression and local invasiveness of tumour (P < 0.05).
Conclusions:
We have studied the expression of MCM2 in a series of ameloblastomas (using an immunohistochemical method) and found this marker to be expressed at high levels; thus, it could potentially serve as a prognostic marker for these aggressive tumors.
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