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Pegfilgrastim (Neulasta)-induced acute aortitis: a case report
Pranay Marlecha1, Samir Kapadia1, Akiva Rosenzveig1
1Sections of Clinical Cardiology and Vascular Medicine Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Desk J3-5 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Granulocyte colony-stimulating factor (G-CSF) can rarely cause acute aortitis, a serious condition. Early diagnosis using PET/CT scans and multidisciplinary management are crucial for patients on G-CSF therapy.
Area of Science:
- Cardiovascular Medicine
- Oncology Supportive Care
- Radiology
Background:
- Granulocyte colony-stimulating factor (G-CSF), particularly pegfilgrastim, is widely used to prevent chemotherapy-induced neutropenia.
- Rarely, G-CSF can trigger large-vessel vasculitis, including aortitis, posing diagnostic and management challenges.
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