Related Experiment Video For Central nervous system
Updated: Jan 12, 2026
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020
Peripheral T-cell lymphoma with central nervous system involvement and elevated interleukin-10 levels in the
Xin Wang1, Haichen Wei1, Dan Liu1
1Department of Lymphoma Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China.
Abstract:
Central nervous system (CNS) involvement in peripheral T-cell lymphoma (PTCL) is rare and is associated with poor prognosis. This report presents two pathologically confirmed PTCL cases. Although cerebrospinal fluid (CSF) flow cytometry did not detect tumor cells, CSF analysis revealed significantly elevated interleukin (IL)-10 levels and an increased IL-10/IL-6 ratio, suggesting CNS involvement. Following effective chemotherapy, which crossed the blood-brain barrier, IL-10 levels and the IL-10/IL-6 ratio decreased significantly, with clinical improvement. These findings suggest that IL-10 is a valuable supplementary diagnostic marker for CNS involvement in PTCL. Whole-brain radiation therapy, as a consolidative treatment, may be effective for residual or refractory lesions and improve prognosis. We review these patients' clinical and diagnostic features and discuss the role of radiotherapy in the treatment of CNS involvement in PTCL.
