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Novel minimal invasive antireflux techniques: A systematic review
Marcus Reuterwall Hansson1, Alexandros Tsoposidis2, Apostolos Analatos3
1Department of Surgery Ersta Hospital 11630 Stockholm Sweden.
Summary
New minimally invasive GERD treatments like Esophyx and LINX offer long-lasting symptom relief and improved quality of life. Further research is needed for MUSE and RefluxStop to establish their clinical roles.
Area of Science:
- Gastroenterology
- Minimally Invasive Surgery
- Medical Device Technology
Background:
- Emergence of novel transoral and minimally invasive techniques for gastroesophageal reflux disease (GERD) treatment.
- Need for rigorous evaluation of the clinical efficacy and safety of these new GERD therapies.
Purpose of the Study:
- To systematically review and evaluate the efficacy and safety of second-generation antireflux procedures.
- To assess the available evidence for Stretta, Esophyx/TIF, MUSE, LINX, and RefluxStop techniques.
Main Methods:
- Systematic literature review adhering to Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines.
- Inclusion of studies with objectively verified GERD and detailed population descriptions.
- Focus on techniques with sufficient clinical efficacy data: Stretta, Esophyx/TIF, MUSE, LINX, RefluxStop.
Main Results:
- Stretta shows long-term efficacy based on randomized controlled trials (RCTs) and cohort data.
- Esophyx demonstrates sustained effectiveness through RCTs and longer-term cohort studies.
- LINX shows comparable efficacy to Esophyx, though documentation is less comprehensive.
- MUSE and RefluxStop require further investigation for long-term outcomes and clinical validation.
Conclusions:
- Esophyx and LINX appear effective for long-lasting GERD symptom control and quality of life improvement, particularly in patients with small hiatal hernias responsive to PPIs.
- MUSE and RefluxStop necessitate more robust clinical data to determine their definitive roles in GERD management.
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