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Updated: Jan 6, 2026
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Benefits of high-normal-dose 18 F-fluorodeoxyglucose PET/computed tomography imaging: a comparative study in
Runjun Yang1,2,3,4, Yunze Xie1,2,3,4, Danjie Cai1,2,3,4
1Department of Nuclear Medicine, Zhongshan Hospital, Fudan University.
Objective:
To investigate the advantages of high-normal-dose 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging in total-body PET/CT and short axial field-of-view (SAFOV) PET/CT systems.
Methods:
This retrospective study initially included 137 patients underwent high-normal-dose (5.55 MBq/kg) 18 F-FDG PET/CT scans. 36 patients who underwent both total-body PET/CT and SAFOV PET/CT scans (G0) were included in the self-control cohort, while 101 patients who underwent only total-body PET/CT scans, formed the exploratory cohort. Total-body PET/CT scans were performed with a 5-min acquisition time, divided into multiple duration groups for the self-control cohort (30s-5 min), and for the exploratory cohort (1min- 5min). Objective image quality parameters included maximum standardized uptake value (SUV max ), mean standardized uptake value (SUV mean ), SD, and signal-to-noise ratio (SNR) of background issues. In addition, SUV max and tumor-to-background ratios were measured for the lesions. In the subsequent matched-pair study, 32 patients who underwent normal-dose 18 F-FDG (3.7 MBq/kg) SAFOV PET/CT (G780') were retrospectively matched with 32 subjects from the self-control cohort (G780).
Results:
In the self-control cohort, SNR, SUV max , and tumor-to-background ratios were significantly higher in all total-body PET/CT groups compared with G0, with stable trends across the total-body PET/CT groups as acquisition time increased. In the exploratory cohort, G3'-G5' demonstrated better lesion detection rates than G1' and G2', but no significant differences were observed. In the matched-pair study, no significant differences were observed between G780 and G780'.
Conclusion:
Compared with the normal-dose protocol, a high-normal dose offers minimal advantages in SAFOV PET/CT systems. Extended acquisition times enhance both objective image quality and lesion detection rates in total-body PET/CT, with optimal performance could reach at 3 min.
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