Investigating Outcomes of Gamete Donation in Assisted Reproductive Technology: A Retrospective Study

Area of Science:

• Reproductive Medicine
• Obstetrics
• Neonatalogy

Background:

• Assisted Reproductive Technology (ART) plays a crucial role in managing infertility.
• Gamete donation is a key component of ART, enabling conception for individuals and couples facing gamete-related challenges.
• Evaluating outcomes of gamete donation cycles is essential for optimizing patient care and success rates.

Purpose of the Study:

• To evaluate and characterize Assisted Reproductive Technology (ART) cycles utilizing gamete donation.
• To analyze the associated obstetric and neonatal outcomes in pregnancies resulting from gamete donation.
• To identify factors influencing ART cycle success and associated risks.

Main Methods:

• Retrospective analysis of 238 gamete donation cycles from 2011-2021.
• Collection of variables including recipient demographics, infertility factors, ART techniques, and pregnancy outcomes.
• Statistical analysis using IBM SPSS Statistics 27 (p<0.05 significance).

Main Results:

• Sperm donation: 29.4% preterm deliveries, 24.3% non-ongoing pregnancies, 47.7% cesarean sections.
• Low birth weight observed in 29.3% of singletons and 69% of twins.
• Oocyte donation: 40% preterm deliveries, 43.4% low birth weight; multiple gestations increased risks.

Conclusions:

• High incidence of multiple gestations in gamete donation ART cycles.
• Recommends single embryo transfer, especially for older oocyte recipients.
• Emphasizes patient education on risks/benefits and comprehensive maternal/fetal monitoring.