Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

547
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
547
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

559
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
559
Depression: Overview01:18

Depression: Overview

735
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
735
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

771
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
771
Cognitive Therapy01:25

Cognitive Therapy

742
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
742
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

406
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
406

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The sound of engagement: assessing the feasibility and acceptability of an AI-generated personalized podcast as a between-session resource for therapy.

Frontiers in digital health·2026
Same author

AI-Powered Documentation for Mental Health Providers: Retrospective Observational Mixed Methods Study.

JMIR formative research·2026
Same author

Older Adult Volunteers' Experiences Delivering a Lay-Led Behavioral Activation Program for Depression Among Community-Dwelling Older Adults: A Mixed Methods Study.

The American journal of geriatric psychiatry. Open science, education, and practice·2025
Same author

Correction: Personalization Strategies for Increasing Engagement With Digital Mental Health Resources: Sequential Multiple Assignment Randomized Trial.

JMIR mental health·2025
Same author

Implementing a suicide risk management protocol as part of a multisite clinical trial: Findings and lessons learned.

Clinical trials (London, England)·2025
Same author

Gender Differences in Trajectories of Depressive Symptoms Among Talkspace Clients: Naturalistic Observational Study.

JMIR formative research·2025

Related Experiment Video

Updated: Jan 6, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

4.0K

Message-Based vs Video-Based Psychotherapy for Depression: A Randomized Clinical Trial.

Michael D Pullmann1, Julien Rouvere1, Patrick J Raue1

  • 1Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle.

JAMA Network Open
|October 30, 2025
PubMed
Summary
This summary is machine-generated.

Message-based psychotherapy (MBP) and video-based psychotherapy (VBP) showed similar depression outcomes. VBP had higher dropout rates, while MBP offers a viable alternative for accessible mental healthcare.

More Related Videos

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

214
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.5K

Related Experiment Videos

Last Updated: Jan 6, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

4.0K
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

214
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.5K

Area of Science:

  • Digital mental health
  • Psychotherapy research
  • Clinical trials

Background:

  • Message-based psychotherapy (MBP) offers asynchronous therapeutic exchanges via digital messages.
  • Video-based psychotherapy (VBP) is a synchronous digital modality.
  • Comparing MBP and VBP is crucial for optimizing digital mental health treatment.

Purpose of the Study:

  • To compare the effectiveness of MBP and VBP for depression.
  • To evaluate combined modalities for non-responders.
  • To assess treatment engagement and therapeutic alliance.

Main Methods:

  • Sequential multiple assignment randomized clinical trial with 850 participants.
  • Randomization to MBP or VBP at baseline; non-responders rerandomized to combined modalities.
  • 12-week treatment duration with depression severity (PHQ-9) as primary outcome.

Main Results:

  • No significant differences in depression or social functioning outcomes between MBP and VBP.
  • Higher treatment disengagement in VBP compared to MBP.
  • VBP showed a stronger initial therapeutic alliance among non-responders.

Conclusions:

  • MBP is a viable alternative to VBP, with comparable clinical outcomes.
  • Improved insurance coverage for MBP could enhance access to care.
  • Further research should focus on optimizing early alliance-building in MBP.