How can nanoemulgels improve the therapeutic benefit of naturally derived compounds?

The growing interest in naturally derived compounds as therapeutic agents has led to an ongoing search for innovative delivery systems that can improve their bioavailability and therapeutic efficacy. Nanoemulgels, a hybrid system that combines the benefits of nanoemulsions and hydrogels, offer a promising approach to enhance the delivery and efficacy of these bioactive compounds. This review presents the pharmaceutical applications of nanoemulgels containing naturally derived compounds, along with the challenges and future perspectives. The review explores the interaction between nanoemulgels and distinct types of natural compounds, highlighting how the formulation can be adjusted to maximize the therapeutic effects of each class of substance. In particular, the challenges and strategies for incorporating unstable compounds into nanoemulgels, ensuring their stability and efficacy over time, are discussed. Nanoemulgels represent a promising and versatile platform for enhancing the therapeutic efficacy of naturally derived compounds. By improving the bioavailability and controlled release profiles of these compounds, nanoemulgels can significantly enhance their therapeutic effects in a variety of clinical settings. The combination of biocompatibility, biodegradability, and versatility makes nanoemulgels an exciting area for future research, particularly in personalized medicine and natural product-based therapies.