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  1. Home
  2. Covid-19 Breakthrough Infections During The Circulation Of Delta And Omicron Variants In Tirana, Albania, April 2021-march 2022.
  1. Home
  2. Covid-19 Breakthrough Infections During The Circulation Of Delta And Omicron Variants In Tirana, Albania, April 2021-march 2022.

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COVID-19 breakthrough infections during the circulation of Delta and Omicron variants in Tirana, Albania, April

Fiona Konomi1,2, Silvia Bino3, Kujtim Mersini4

  • 1Department of Epidemiology and Environmental Health, Local Public Health Care Directorate, Tirana, Albania.

Plos One
|October 30, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

COVID-19 breakthrough infections were significantly higher during the Omicron variant surge and in younger individuals. Booster vaccinations are recommended to mitigate future breakthrough cases.

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Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Vaccinology

Background:

  • COVID-19 breakthrough infections raise concerns about vaccine effectiveness and public health.
  • Understanding transmission dynamics is crucial for effective mitigation strategies.

Purpose of the Study:

  • To describe COVID-19 vaccine breakthrough infections in Tirana during the Delta and Omicron variant periods.
  • To inform public health and vaccination strategies based on observed trends.

Main Methods:

  • Data extracted from Albanian infectious disease surveillance and national vaccination databases (April 2021-March 2022).
  • Defined breakthrough infection as a positive SARS-CoV-2 test ≥14 days after primary vaccination series.
  • Calculated infection risk and risk ratios using binomial regression.

Main Results:

  • Over 9,000 breakthrough infections (3.1%) detected among 291,445 fully vaccinated individuals.
  • Higher risk of breakthrough infection observed in younger adults (0-39 years) and during the Omicron period (RR=32).
  • Specific vaccines (Gam-COVID, Vaxzervria, Comirnaty) showed higher breakthrough risks compared to CoronaVac.

Conclusions:

  • COVID-19 breakthrough infections surged during the Omicron variant period, particularly in younger populations.
  • Declining protection after five months and increased Omicron risk necessitate monitoring and adaptive vaccination strategies.
  • Promoting booster vaccinations is essential to reduce future breakthrough infections.