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Idiotype suppression by maternal influence.

I J Weiler, E Weiler, R Sprenger

    European Journal of Immunology
    |September 1, 1977
    PubMed
    Summary
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    Maternal immunization with the J558 idiotype suppressed anti-dextran (Dex) antibody production in offspring. This idiotype-specific suppression was inherited and persisted for months, demonstrating a novel form of immune tolerance.

    Area of Science:

    • Immunology
    • Genetics

    Background:

    • Antibodies to alpha-(1-3) glucosidic linkages in dextrans (Dex) can share the idiotype of the BALB/c myeloma protein J558.
    • Both the specific antibody and its idiotype are inherited dominantly and linked to the immunoglobulin (Ig) heavy chain allotype Igla in BALB/c mice.

    Purpose of the Study:

    • To investigate the suppression of anti-dextran (Dex) antibodies in F1 hybrid mice by maternal immunization with the J558 idiotype.
    • To determine the duration and heritability of this idiotype-specific immune suppression.

    Main Methods:

    • SJL mothers were immunized with the J558 idiotype to induce suppression in their F1 progeny (SJL x BALB/c).
    • Progeny were tested for anti-Dex antibodies, inhibition by anti-J558 idiotype serum, presence of the J558 idiotype, and lambda1 chain concentration.

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  • Suppression was assessed in multiple litters over 4-5 months, and spleen cells from suppressed mice were used to transfer suppression.

    • Main Results:

    • Maternal immunization with the J558 idiotype successfully suppressed the expression of anti-Dex antibodies in F1 progeny.
    • Suppression was observed in successive litters and persisted in F1 animals for 16 weeks or longer.
    • Spleen cells from suppressed F1 mice could confer suppression to naive newborn F1 mice, indicating a transmissible suppressive state.

    Conclusions:

    • Maternal immunization with a specific idiotype can induce a long-lasting, inherited suppression of the corresponding antibody response in offspring.
    • This study demonstrates a novel mechanism of immune tolerance mediated by idiotype-specific suppression, potentially transferable via cells.