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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Injectables Protein-Based Nanodiscs in Cancer Drug Delivery: From Bench to Clinical Potential.

Vimal Patel1, Jigar N Shah2, Saloni Dalwadi3

  • 1Department of Pharmaceutics, School of Pharmacy, P P Savani University, Surat, 394125, Gujarat, India.

AAPS Pharmscitech
|October 31, 2025
PubMed
Summary
This summary is machine-generated.

Protein nanodiscs (NDs) offer a novel approach for cancer therapy by mimicking cell membranes to deliver drugs and nucleic acids. These nanostructures enhance drug efficacy and reduce side effects by targeting cancer cells.

Keywords:
Cancer therapeuticsClinical trialsMembrane mimicking nanodiscPersonalized medicines

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cancer Therapeutics

Background:

  • Protein nanodiscs (NDs) are nanoscale constructs featuring a lipid bilayer and scaffold protein, mimicking cell membranes.
  • They serve as platforms for studying membrane proteins and have emerged as nano-formulations for cancer drug delivery.

Purpose of the Study:

  • To review the potential of membrane-mimicking protein nanodiscs in cancer therapeutics.
  • To discuss their structural components, stability, synthesis, limitations, and clinical implications.

Main Methods:

  • Review of existing literature on protein nanodiscs for cancer therapy.
  • Analysis of nanodisc structure, stability, and functionalization strategies.
  • Evaluation of therapeutic advancements and future challenges.

Main Results:

  • NDs can be functionalized with targeting ligands for specific cancer cell binding.
  • ND formulations protect macromolecules, enhance pharmacokinetics, and enable controlled drug release.
  • NDs demonstrate potential for improved therapeutic efficacy and reduced toxicity.

Conclusions:

  • Membrane-mimicking protein nanodiscs represent a versatile platform for macromolecular delivery in oncology.
  • Further research is needed to address stability, synthesis, and clinical translation challenges.
  • NDs hold promise for precise cancer cell targeting and enhanced therapeutic outcomes.