From Liquid SNEDDS to Solid SNEDDS: A Comprehensive Review of Their Development and Pharmaceutical Applications

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Nanotechnology

Background:

• Self-nano-emulsifying drug delivery systems (SNEDDS) are crucial for improving the solubility and bioavailability of hydrophobic drugs.
• Both liquid and solid SNEDDS formulations offer enhanced drug absorption, but selection depends on factors like portability, patient compliance, and preparation ease.

Purpose of the Study:

• To provide a comprehensive analysis of liquid and solid SNEDDS formulations.
• To guide researchers in choosing the optimal SNEDDS dosage form by examining production and performance factors.
• To explore the role of artificial intelligence in SNEDDS formulation design.

Main Methods:

• Review of literature on SNEDDS formulations, focusing on excipient characteristics and stability.
• Analysis of liquid-to-solid preparation methods, including associated challenges.
• Comparison of in vivo and in vitro performance of liquid versus solid SNEDDS.

Main Results:

• Both liquid and solid SNEDDS enhance drug bioavailability.
• Key considerations for formulation selection include portability, patient compliance, administration route, and ease of preparation.
• Excipient selection, stability, and manufacturing processes significantly impact SNEDDS performance.

Conclusions:

• The choice between liquid and solid SNEDDS depends on specific application requirements and desired drug delivery characteristics.
• Further research into artificial intelligence applications can optimize SNEDDS formulation development.
• SNEDDS represent a promising platform for advanced drug delivery, particularly for poorly soluble compounds.