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  3. Clinical And Microbiological Characteristics Of Bacteremia In Pediatric Intensive Care Unit: A Retrospective Analytical Observational Study.
  1. Home
  3. Clinical And Microbiological Characteristics Of Bacteremia In Pediatric Intensive Care Unit: A Retrospective Analytical Observational Study.

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Clinical and microbiological characteristics of bacteremia in pediatric intensive care unit: a retrospective

Junli Shan1, Yan Gao2, Jiaqi Su2

  • 1Department of Pediatrics, Qilu Hospital of Shandong University, No.107 West Wenhua Road, Jinan, Shandong Province, 250012, China.

BMC Pediatrics
|October 31, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Pediatric intensive care unit (PICU) bacteremia increases mortality risk. Early identification of risk factors like platelet count and lactate levels is crucial for improving survival in critically ill children.

Keywords:
BacteremiaInfectionMortalityPediatric intensive care unitRisk factors

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Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Clinical microbiology

Background:

  • Bacteremia in the pediatric intensive care unit (PICU) poses a significant threat to critically ill children.
  • Prompt clinical recognition and intervention are vital to mitigate severe outcomes and prevent fatal progression.

Purpose of the Study:

  • To analyze the clinical characteristics, causative organisms, antimicrobial resistance patterns, and mortality predictors in pediatric patients with bacteremia in the PICU.
  • To identify factors associated with increased mortality and prolonged hospital stays in this vulnerable population.

Main Methods:

  • A retrospective observational study analyzed data from 9,814 pediatric patients (28 days to 18 years) admitted to the PICU between 2010 and 2018.
  • Clinical data, blood culture results, drug resistance profiles, and patient outcomes were extracted and analyzed.

Main Results:

  • Bacteremia was identified in 6.42% of patients, with an in-hospital mortality rate of 12.70%.
  • Patients with bacteremia exhibited distinct laboratory abnormalities, including lower platelet (PLT) counts and albumin, and higher C-reactive protein (CRP) and lactate levels.
  • Independent predictors of mortality in bacteremic patients included PLT count, activated partial thromboplastin time (APTT), and lactate. Fungal and Gram-negative bacteremia, as well as multidrug-resistant infections, were associated with higher case fatality rates.

Conclusions:

  • Bacteremia in the PICU is a significant independent risk factor for increased mortality.
  • Early identification and management of risk factors, such as specific laboratory values and pathogen types, are essential for improving patient survival and clinical outcomes.