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Chronic Rhinosinusitis: Review of Endotypes and Clinical Implications
Tom Raz Yarkoni1, Elchanan Zloczower2, William Jared Martin1
1Department of Otolaryngology - Head & Neck Surgery, University of North Carolina, Chapel Hill, NC, USA.
Purpose Of Review:
The purpose of the review is to summarize current literature and evaluate the clinical implications of chronic rhinosinusitis (CRS) endotypes.
Major Findings:
Evolving understanding of CRS endotypes has reshaped the approach to diagnosis and treatment, from a simple phenotypic classification to a more precise molecular and immunologic framework. The differentiation between type 2 and non-type 2 inflammation has led to the development of targeted and precise therapeutic approaches, particularly with the introduction of biologic agents.
Conclusions:
Future advances in biomarker identification and personalized medicine will continue to further refine CRS management by supporting individualized, endotype-specific therapies that improve treatment outcomes.
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