Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

518
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
518
Insomnia01:27

Insomnia

388
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
388
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

343
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
343
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

497
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
497
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

394
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
394
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

820
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
820

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risks Associated With Benzodiazepine Long-Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta-Analysis.

Journal of sleep research·2026
Same author

Lights On or Off? The Efficacy of Light Therapy as Add-On to Cognitive Behavioural Therapy for Insomnia-A Pilot Study.

Journal of sleep research·2026
Same author

Association Between Sleep Quality and Oxidative Stress in Postoperative Cardiovascular Patients-A Pilot Study.

Journal of sleep research·2026
Same author

How personality functioning shapes symptom development during and after treatment: A random intercept cross lagged panel analysis.

Comprehensive psychiatry·2026
Same author

Ru-SATED scale and Sleep Health Index: A systematic review of two leading multidimensional sleep health measures and frameworks across the globe.

Sleep medicine reviews·2026
Same author

Obsessive-compulsive symptoms and inflammatory brain changes detected using an innovative multimodal diagnostic work-up.

Journal of neuroimmunology·2026
Same journal

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin-1 Levels.

Journal of sleep research·2026
Same journal

Continuous Positive Airway Pressure Versus Mandibular Advancement Devices Impact on Cardio-Metabolic Outcomes in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Journal of sleep research·2026
Same journal

Strong and Weak Episodic Memories Are Shaped by Multiple Cycles of NREM Spindles and REM Alpha Bursts.

Journal of sleep research·2026
Same journal

A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia.

Journal of sleep research·2026
Same journal

Thoracoabdominal Asynchrony in Healthy Children.

Journal of sleep research·2026
Same journal

Chronotype and Time of Day Effects in Oddball Task Performance: Behavioural and Cerebral Correlates.

Journal of sleep research·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.0K

Daytime Performance in Insomnia Patients.

Sibylle Frase1, Katharina Domschke2, Bernd Feige2

  • 1Department of Neurology and Neuroscience, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Journal of Sleep Research
|October 31, 2025
PubMed
Summary
This summary is machine-generated.

Nonorganic Insomnia (NI) patients do not show impaired general vigilance or alertness despite subjective daytime issues. This study suggests subtle neurocognitive changes may relate to hyperarousal rather than sleep loss.

Keywords:
alertnesscognitive functioningdaytime functioningfatiguesleepsleepinessvigilance

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.6K
Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

8.2K

Related Experiment Videos

Last Updated: Jan 12, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.0K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.6K
Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

8.2K

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Cognitive Psychology

Background:

  • Nonorganic Insomnia (NI) significantly impacts patients' quality of life through daytime impairments.
  • Objective data on measurable cognitive deficits in NI patients are often heterogeneous.
  • Existing research lacks clear operationalized criteria for daytime symptoms in NI.

Purpose of the Study:

  • To objectively assess daytime performance in NI patients using neuropsychological testing.
  • To correlate cognitive performance with polysomnography (PSG) and self-report data.
  • To investigate potential differences in cognitive function between NI patients with and without comorbidities.

Main Methods:

  • Neuropsychological tests were administered to 329 NI patients.
  • Self-report questionnaires assessed subjective daytime impairments.
  • Results were correlated with polysomnographic data, including arousal markers.

Main Results:

  • Neuropsychological tests showed no general impairment in vigilance or alertness in NI patients.
  • A positive correlation was found between performance and nocturnal arousal markers, particularly during REM sleep.
  • A slight deficit was observed in increasing focus during the phasic compared to tonic alertness paradigm.

Conclusions:

  • The study found no evidence of diminished general vigilance or alertness due to sleep loss in NI patients.
  • Conflicting evidence on neurocognitive deficits in insomnia may stem from distinguishing alertness deficits from subtle processing changes.
  • Subtle neurocognitive changes in NI might be better explained by hyperarousal and anxiety rather than sleep deprivation.