Resveratrol as a Regulator of Inflammation, Oxidative Stress, and Glucose Stability in Diabetes

Diabetes mellitus, a complex metabolic disorder, proves to be a challenge for the population around the world, as it includes chronic inflammation, oxidative stress, and glucose dysregulation. Resveratrol is a naturally occurring compound that acts as a diabetes complication- mitigating agent through complex cellular maneuvers and acts specifically to remedy diabetes complications. This review focuses on the action of resveratrol, underlining its vital impact in the alteration of significant pathophysiological pathways in diabetes. Besides, the activation of the AMPK and SIRT1 pathways also greatly improved cellular stress responses as well as insulin sensitivity. Numerous clinical studies have validated that the implementation of natural polyphenols' supplementation enhances glucose control, diabetes, inflammation, and insulin sensitivity, which supports these study findings. Its clear safety profile and flexible bioavailability also enhance its position as an adjunct diabetes therapy. As promising as that is, some issues still need to be addressed, including tackling standardized challenges like dosage issues and bioavailability.