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Severe Necrotizing Pneumonia Caused by Panton‑Valentine Leukocidin‑Producing Staphylococcus aureus in a Previously

Prabin Paudyal1, Pallavi Bedi2

  • 1Internal Medicine, University Hospital Hairmyres, NHS Lanarkshire, Glasgow, GBR.

Cureus
|October 31, 2025
PubMed

Insights

A severe necrotizing pneumonia case was caused by Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus. Early recognition and targeted treatment of PVL-SA are crucial for preventing severe complications in healthy individuals.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Microbiology

Background:

  • Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus (PVL-SA) is an emergent pathogen.
  • PVL-SA is associated with severe skin and soft tissue infections and invasive disease.
  • Necrotizing pneumonia caused by PVL-SA can rapidly progress to respiratory failure.
Keywords:
necrotizing pneumoniapanton‑valentine leukocidinrespiratory failurestaphylococcus aureustoxin suppression therapy

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