Related Experiment Video
Updated: Jan 12, 2026
11:38
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
12.7K
Incorporating High-Risk Individuals Beyond Smoking History Into Lung Cancer Screening in Hong Kong: A
Herbert Ho-Fung Loong1, Xuanqi Pan2,3, Carlos K H Wong1,4,5,6
1Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.
JTO Clinical and Research Reports
|October 31, 2025
Summary
Lung cancer screening (LCS) using low-dose computed tomography (LDCT) is cost-effective in Hong Kong for high-risk individuals, including non-smokers. This approach can reduce lung cancer mortality and improve population health outcomes.
Area of Science:
- Public Health
- Health Economics
- Oncology
Background:
- Lung cancer (LC) is a leading cause of cancer death in Hong Kong, with a significant proportion of cases occurring in never-smokers.
- Traditional lung cancer screening (LCS) focuses on smoking history, which may not capture the full spectrum of high-risk individuals in diverse populations.
- Low-dose computed tomography (LDCT) has shown potential in reducing LC mortality, but its cost-effectiveness needs evaluation within specific epidemiological contexts.
Purpose of the Study:
- To conduct a cost-effectiveness analysis of LCS using LDCT in Hong Kong.
- To evaluate LCS for both smoking-related and non-smoking-related high-risk individuals.
- To inform public health policy regarding LCS implementation.
Main Methods:
- A decision tree and Markov model were employed to simulate LCS outcomes from a healthcare provider perspective.
- Data from the Dutch-Belgian Lung Cancer Screening Study (for smokers) and the Taiwan Lung Cancer Screening in Never-Smoker Trial (for non-smokers) were adapted.
- Local Hong Kong data on LC survival, costs, and a willingness-to-pay threshold (US$24,302–US$40,202 per QALY) were utilized.
Main Results:
- LCS with LDCT demonstrated increased early detection of LC and reduced LC mortality compared to no screening.
- The incremental cost-effectiveness ratio (ICER) for smoking-history-based high-risk individuals was US$14,122 per QALY.
- The ICER for non-smoking-history-based high-risk individuals was lower, at US$9610 per QALY.
Conclusions:
- LCS with LDCT is a cost-effective strategy in Hong Kong for both smoking-related and non-smoking-related high-risk individuals.
- The findings support expanding LCS to encompass all identified high-risk individuals, beyond just those with a smoking history.
- Implementing population-based LCS can significantly contribute to improving overall population health by reducing lung cancer burden.
Related Concept Videos
01:25Statistical Methods for Analyzing Epidemiological Data
889
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
889
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
395
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
395
02:20Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K