Related Experiment Video
Updated: Jul 6, 2026
Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis
Published on: March 22, 2016
Green-synthesized cardamom-modified iron oxide nanoparticles with potent antibacterial, antioxidant,
Swagota Briti Ray Gupta1, Shourav Paul2, Md Abdul Momin3
1Microbiology Laboratory, Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Rajshahi Rajshahi-6205 Bangladesh saleh@ru.ac.bd szaman@ru.ac.bd.
Abstract:
Cancer and antimicrobial resistance pose significant global health challenges, necessitating the development of novel therapeutic approaches. This study presents the green synthesis of (3-aminopropyl)trimethoxysilane (APTMS)-modified iron oxide nanoparticles coated with Elettaria cardamomum extract (EC-AMIONPs) via a co-precipitation method. The synthesized nanoparticles were thoroughly characterized using UV-vis, FTIR, SEM, EDX, XRD, TGA, and VSM techniques. The analyses confirmed the successful formation of spherical, amorphous EC-AMIONPs with an average size of 14.28 nm and paramagnetic properties. Phytochemical screening revealed the presence of bioactive compounds, including terpenoids, steroids, alkaloids, tannins, and phenols. Functionally, EC-AMIONPs exhibited potent antioxidant activity (80.75% at 100 μg mL-1), broad-spectrum antibacterial effects against multidrug-resistant pathogens, and significant antibiofilm capacity. The anti-inflammatory potential was demonstrated through the inhibition of albumin denaturation (76.92%), stabilization of HRBC membranes (78.85%), and proteinase inhibition (73.36%) at 200 μg mL-1. Cytotoxicity, assessed via the Artemia salina assay, revealed moderate toxicity (65.00% lethality at 400 μg mL-1; LC50: 170.35 μg mL-1), supporting their biosafety at therapeutic doses. In vivo studies in EAC-induced mice confirmed the anticancer efficacy of EC-AMIONPs, resulting in a significant reduction in tumor growth and improvement in physiological parameters, including hematological (RBC, WBC, hemoglobin), biochemical (ALT, creatinine, lipid profile), and ionic (Na+, K+, Ca2+, Cl-) profiles. Histological analysis further validated the protective effects on liver, kidney, lung, and intestinal tissues. Overall, EC-AMIONPs demonstrate multifunctional biomedical properties-antioxidant, antibacterial, anti-inflammatory, and anticancer-highlighting their potential as a green nanoplatform for future therapeutic applications.
