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Updated: Jan 12, 2026
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Molecular markers in triple-negative breast cancer: A retrospective correlation study
Sudarshan Gupta1, Purti Agrawal Saini2, Vikas Pandey3
1Department of Pathology, VKS Government Medical College, Neemuch, Madhya Pradesh, India.
None:
The expression and clinical correlation of molecular markers in 128 patients diagnosed with triple-negative breast cancer (TNBC). Immunohistochemistry was used to assess markers including Ki-67, p53, EGFR and CK5/6. High Ki-67 and p53 positivity were significantly associated with higher tumor grade and lymph node involvement. EGFR and CK5/6 expression correlated with basal-like features and poor differentiation. Data suggest that molecular profiling in TNBC may guide prognosis and targeted therapies.
