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Current trends on immunotherapy for oncology.
Neya Kavya Chander1, Prashannalakshmi A2, Phanish Chandra Ravi3
1Institute of Internal Medicine, Madras Medical College & Rajiv Gandhi Government General Hospital, Chennai, India.
Bioinformation
|October 31, 2025
Summary
Immunotherapy, including immune checkpoint inhibitors and CAR T-cell therapy, has transformed cancer treatment. Ongoing research focuses on overcoming resistance and toxicity to improve patient outcomes with novel strategies and personalized approaches.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Immunotherapy harnesses the patient's immune system to fight cancer, revolutionizing oncology.
- Immune checkpoint inhibitors (ICIs) and CAR T-cell therapies are established treatments for various cancers.
- Significant challenges remain, including treatment resistance, immune-related toxicities, and high costs.
Purpose of the Study:
- To review the current landscape of cancer immunotherapy.
- To discuss emerging strategies aimed at overcoming existing limitations.
- To highlight the importance of biomarkers and combination therapies.
Main Methods:
- Review of current immunotherapeutic agents and their mechanisms.
- Exploration of novel therapeutic targets and modalities.
- Discussion of strategies for patient selection and treatment optimization.
Main Results:
- ICIs targeting CTLA-4, PD-1, and PD-L1 are standard care for solid tumors.
- CAR T-cell therapy shows high efficacy in hematologic malignancies.
- Emerging strategies like novel checkpoint inhibitors, cellular therapies, vaccines, and oncolytic viruses are under investigation.
Conclusions:
- Despite successes, resistance and toxicity limit immunotherapy's broad application.
- Novel targets, next-generation therapies, and personalized approaches are crucial for advancing cancer treatment.
- Biomarker development and combination regimens are key to enhancing efficacy and patient outcomes.
Keywords:
CAR T-cell therapyCancer immunotherapycombination therapyimmune checkpoint inhibitorsimmune-related adverse eventsprecision oncologytumor microenvironmentMore Related Videos
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