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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Giant Cell Arteritis Manifesting as Area Postrema Syndrome: A Case Report
Caitlin Courtney1, Catherine Franconi1, Ferry Dharsono2
1Neurology, Royal Perth Hospital, Perth, AUS.
Cureus
|October 31, 2025
Summary
Giant cell arteritis (GCA) can cause area postrema syndrome (APS), leading to severe neurological symptoms like intractable nausea and vomiting. Early diagnosis and treatment with corticosteroids and IL-6 inhibitors can resolve APS and its underlying GCA cause.
Area of Science:
- Neurology
- Vascular Neurology
- Rheumatology
Background:
- Area postrema syndrome (APS) is characterized by nausea, vomiting, and hiccups, often indicating brainstem involvement.
- Giant cell arteritis (GCA) is a systemic vasculitis that can affect cranial arteries, potentially leading to neurological complications.
- Vertebral artery stenosis is a recognized risk factor for posterior circulation ischemic events.
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