Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic variants of alcoholic hyalin.

H Yokoo, O T Minick, F Batti

    The American Journal of Pathology
    |October 1, 1972
    PubMed
    Summary

    Alcoholic hyalin in liver disease is a fibrillar deposit, not giant mitochondria. Fine filaments associated with it suggest a host cell contractile system response to hepatic injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Understanding the experiences of people with disfigurements: An integration of four models of social and psychological functioning.

    Psychology, health & medicine·2017
    Same author

    Long-term effect of epidural injection with sustained-release lidocaine particles in a rat model of postoperative pain.

    British journal of anaesthesia·2012
    Same author

    Rural housing.

    Journal. Royal Sanitary Institute (Great Britain)·2010
    Same author

    The Movement of Iron-Laden Lysosomes in Rat Liver Cells During Mitosis.

    The American journal of pathology·2009
    Same author

    A survey of the UK maxillofacial laboratory service: profiles of staff and work.

    The British journal of oral & maxillofacial surgery·2005
    Same author

    Strengthening the parent-child relationship: a review of family interventions and their use in medical settings.

    Child: care, health and development·2005

    Area of Science:

    • Hepatology
    • Cell Biology
    • Pathology

    Background:

    • Alcoholic liver disease is a major cause of chronic liver damage.
    • Alcoholic hyalin is a characteristic ultrastructural finding in hepatocytes of patients with alcoholic liver disease.
    • The precise nature and origin of alcoholic hyalin remain incompletely understood.

    Purpose of the Study:

    • To characterize the ultrastructure of alcoholic hyalin.
    • To investigate the relationship between alcoholic hyalin and other cellular components.
    • To explore the potential origin and function of alcoholic hyalin.

    Main Methods:

    • Light and electron microscopy were used to examine liver biopsies from 24 patients with alcoholic liver disease.
    • Adjacent tissue sections were compared to differentiate cellular structures.
    • Morphologic analysis focused on the fibrillar nature and associations of alcoholic hyalin.

    Main Results:

    • Alcoholic hyalin is a fibrillar deposit lacking limiting membranes, distinct from giant mitochondria.
    • This fibrillar structure was observed in hepatocytes, ductular cells, and hepatomas.
    • Three forms of alcoholic hyalin were identified: parallel arrays, random clusters, and amorphous substance.
    • Fine filaments, similar to those in hyalin, were found in excess in non-hyalin cells, suggesting a common origin.

    Conclusions:

    • Alcoholic hyalin is a fibrillar deposit originating from host cells.
    • The associated fine filaments suggest a role for a contractile system in hepatic injury response.
    • These findings provide new insights into the pathogenesis of alcoholic liver disease.

    Related Experiment Videos