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Related Concept Videos

The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Mini review: Persister cell control strategies.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Bacterial persisters are non-mutant, dormant cells exhibiting high tolerance to antibiotics.
  • Their dormancy allows survival during antibiotic treatment and regrowth upon withdrawal.
  • Persister cells pose a significant challenge to eradicating bacterial infections.

Purpose of the Study:

  • To review current strategies for controlling bacterial persister cells.
  • To identify future research opportunities in persister cell management.
  • To encourage further investigation into this critical area of infection control.

Main Methods:

  • Literature review of existing persister cell control strategies.
  • Analysis of the mechanisms underlying persister cell formation and tolerance.
  • Discussion of potential therapeutic interventions and future research directions.

Main Results:

  • Current strategies include targeting persister cell formation, dormancy mechanisms, or regrowth.
  • Combinatorial therapies and novel compounds show promise in eliminating persisters.
  • Understanding persister cell heterogeneity is key to developing effective treatments.

Conclusions:

  • Effective control of bacterial persisters requires multifaceted approaches.
  • Further research into persister cell biology and novel eradication methods is essential.
  • Addressing persister cells is critical for overcoming antibiotic tolerance and improving infection outcomes.