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Updated: Jan 6, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two-Sample Mendelian Randomization Study
Hui Cheng1,2, Dayuan Zhong1
1Nanhai Hospital of Traditional Chinese Medicine Jinan University Foshan China.
Background And Objective:
This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets.
Methods:
Instrumental variables were derived from genome-wide association study (GWAS) data on 4907 circulating proteins. Causal associations between exposures and outcome were assessed using MR analysis. Sensitivity analyses were conducted to identify circulating proteins most strongly associated with hyperlipidemia. Finally, enrichment analysis was performed on positively associated proteins to identify disease-related pathways.
Results:
MR analysis identified 70 disease-associated proteins, including 47 positively correlated and 23 negatively correlated with hyperlipidemia. Enrichment analysis revealed significant pathways related to hyperlipidemia, such as the adipocytokine signaling pathway and axon guidance.
Conclusion:
This study identified several circulating proteins significantly associated with hyperlipidemia. The large sample size minimized confounding factors, providing valuable insights for clinical treatment strategies.
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