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Updated: Jan 12, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Developments in small-molecule soluble epoxide hydrolase inhibitors: synthetic advances and therapeutic applications
Zhen-Yue Wang1, Jing-Yue Dong1, Jian-Hua Liang1
1Key Laboratory of Medicinal Molecule Science and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, P. R. China.
Abstract:
The development of soluble epoxide hydrolase (sEH) inhibitors has emerged as a promising therapeutic strategy, yet progress has been constrained by structural similarity and suboptimal pharmacokinetic profiles. While numerous synthetic and natural product-derived inhibitors demonstrate potent pharmacological activity, their clinical translation has been hampered by recurring limitations including poor solubility, low AUC, CYP inhibition, and hERG toxicity. This review critically evaluates recent breakthroughs in scaffold diversification and rational design approaches that overcome these limitations. We highlight innovative synthetic methodologies, structure-activity relationship insights, and novel chemotypes that expand the chemical space beyond conventional urea-based scaffolds. Furthermore, we discuss emerging therapeutic applications enabled by these advanced inhibitors, providing a strategic roadmap for next-generation sEH-targeted drug discovery.
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