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Folding and Characterization of a Bio-responsive Robot from DNA Origami
Published on: December 3, 2015
Self-assembled DNA nanodevices for intelligent biosensing
Yongjian Chen1,2, Run Tian1,2, Yi Zhang3
1CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. dingbq@nanoctr.cn.
None:
Leveraging sequence specificity, shape programmability, and spatial addressability, DNA nanotechnology enables the nanometer-precise construction of DNA nanodevices for a wide range of biological applications. This minireview summarizes recent progress in employing self-assembled DNA nanostructures as scaffolds for creating advanced nanodevices as biosensors. We highlight notable advancements in ultrasensitive detection, multiplexed sensing, and targeted molecular bioimaging. These self-assembled DNA nanodevices are designed for intelligent sensing of various analytes, offering innovative solutions for biomedical diagnostics and environmental surveillance. Challenges related to the detection precision, stability, and scalable production of these promising DNA-based biosensors are also discussed.

