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Boosting Cancer Chemotherapy through Targeted Akkermansia muciniphila Modulation by Tumor-Repopulating Cell-Derived
Shiyu Li1, Nana Bie1,2,3, Xiaojuan Wang1
1National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
None:
The complex relationship between gut microbiota and cancer therapy has received extensive attention, proposing gut microbiota modulation as a promising strategy for enhancing anticancer efficacy. In this work, tumor-repopulating cell-derived microparticles (3D-MPs) encapsulated with doxorubicin (DOX) are developed to improve cancer treatment outcomes through targeted interaction with gut microbiota, particularly Akkermansia muciniphila (AKK). This delivery system efficiently accumulates in the intestines via the integrin α5-fibronectin pathway, promoting AKK abundance through the pro-proliferative effects of 3D-MPs on AKK and the inhibitory action of DOX on competing gut bacteria, such as Helicobacter and Prevotella, for improved anticancer effects. Our findings demonstrate the potential of leveraging gut microbiota modulation to optimize therapeutic outcomes in cancer treatments, offering a novel approach to synergistic cancer therapy.
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