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Published on: May 12, 2023
Ligand exchange of tris(2,4-di-tert-butylphenyl) phosphite: a practical and efficient route to organo gold(I)
David Vesseur1, Shuo Li1, Sonia Mallet-Ladeira2
1Université de Toulouse, CNRS, Laboratoire Hétérochimie Fondamentale et Appliquée (LHFA, UMR 5069), 118 Route de Narbonne, 31062 Cedex 09 Toulouse, France. d.vesseur@uva.nl.
Abstract:
Tris(2,4-di-tert-butylphenyl)phosphite (2,6-tBu2-PhO)3P is used as a stable, easily displaceable ancillary ligand in the preparation of organo Au(I) complexes. The phosphite gold(I) precursors are bench-stable and readily accessible. They undergo high-yielding ligand exchange with a variety of ligands such as phosphines, N-heterocyclic carbenes and bidentate ligands. This ligand exchange strategy overcomes the limitations associated with traditional gold halide-based synthetic routes and is compatible with different organogold fragments. The protocol is scalable, operationally simple and broadly applicable.
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