Related Experiment Video
Updated: Jan 12, 2026

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Does routine estimated glomerular filtration rate reporting adversely affect medication dosing in an older
Gina Davis1, Brendan Smyth2,3, Matthew Kinchington4
1Department of Renal Medicine, Prince of Wales Hospital, Sydney, New South Wales, Australia.
None:
Historically, Cockcroft-Gault (CG) estimated creatinine clearance (eCrCl) was recommended for drug dosing in the presence of kidney disease, but standard pathology reports only include estimated glomerular filtration rate (eGFR). This single-centre retrospective cohort study of 162 patients ≥65 years old examined whether drug dosing errors occurred more commonly when using eGFR versus eCrCl. Of just over 200 medications requiring dose adjustment for GFR, one in eight had a potential prescribing error regardless of the method of estimating GFR. Use of CKD-EPI eGFR rather than CG eCrCl explained only a minority of potential prescribing errors, with no observed clinical consequences.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Drug Dosing: Geriatric Patients
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

