Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Erythropoiesis

Erythropoiesis

Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Lifecycle of Erythrocytes

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....

Oxygen Transport in the Blood

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factors associated with delayed diagnosis of fibrotic interstitial lung disease: a retrospective cohort study.

BMC pulmonary medicine·2026

Same author

Paroxysmal Nocturnal Hemoglobinuria Presenting With Progressive Biventricular Thrombi.

Case reports in hematology·2026

Same author

'Medical Haematology' via systems-based haematology.

British journal of haematology·2026

Same author

Perioperative management of Evans Syndrome for free tissue transfer: Case report and recommendations.

JPRAS open·2026

Same author

Development and Implementation of a Standardized Inpatient Fellow Hematology Curriculum: Enhancing Educational Experiences.

Journal of cancer education : the official journal of the American Association for Cancer Education·2026

Same author

Blood Board: A virtual community of practice for classical hematology education and care improvement.

Blood cells, molecules & diseases·2026

Search research articles

Related Experiment Video

Updated: Jan 12, 2026

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology

Published on: March 22, 2024

Paroxysmal Nocturnal Hemoglobinuria.

Richard C Godby¹, Surbhi Shah²

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings

|October 31, 2025

Summary

This summary is machine-generated.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder causing red blood cell destruction. Early diagnosis and new treatments improve outcomes, though stem cell transplant offers a cure.

More Related Videos

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Published on: January 21, 2020

Related Experiment Videos

Last Updated: Jan 12, 2026

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology

Published on: March 22, 2024

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Published on: January 21, 2020

Area of Science:

Hematology
Immunology
Genetics

Background:

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal disorder.
Characterized by complement-mediated intravascular hemolysis, leading to anemia, fatigue, and thrombosis.
Historically associated with high morbidity and mortality.

Purpose of the Study:

To provide a contemporary review of paroxysmal nocturnal hemoglobinuria (PNH).
Focusing on pathophysiology, epidemiology, clinical manifestations, diagnosis, treatment, and outcomes.
Emphasis on intravascular hemolysis and advancements in targeted therapies.

Main Methods:

Review of clinically relevant articles from MEDLINE.
Synthesis of contemporary data on PNH.
Focus on classic PNH features and current treatment landscape.

Main Results:

Complement inhibitors have transformed PNH treatment, improving prognosis.
Allogeneic hematopoietic stem cell transplant remains the only curative option.
Early diagnosis and treatment are crucial for better outcomes.

Conclusions:

PNH management has significantly improved due to targeted therapies.
Ongoing research and novel treatments continue to enhance patient outlook.
A comprehensive understanding of PNH is vital for effective clinical management.