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Research progress of DUB enzyme in breast cancer

Wei Tang1, Ning Li2, Jianjun Lai3

  • 1Department of Breast and Thyroid Surgery, Feicheng People's Hospital, Taian, 271600, China.

Clinical and Experimental Medicine
|October 31, 2025
PubMed

Insights

Deubiquitinases (DUBs) play a crucial role in breast cancer (BC) progression and drug resistance. Understanding DUBs, particularly USP and OTU families, offers new therapeutic targets for advanced breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer (BC) is the second most common cancer globally, with advanced stages facing significant drug resistance.
  • Current treatments offer limited survival benefits for advanced BC patients.
  • Ubiquitination, a key post-translational modification, regulates protein stability and cellular processes, and its dysregulation is implicated in cancer.

Purpose of the Study:

  • To review the role of deubiquitinases (DUBs) in breast cancer.
  • To explore the structure, function, and aberrant expression of DUBs in BC.
  • To highlight specific DUB families, USP and OTU, in the context of breast cancer.

Main Methods:

  • Literature review of DUBs in breast cancer.
  • Analysis of DUBs' involvement in tumorigenesis and drug resistance.
  • Focus on USP and OTU families based on existing research.

Main Results:

  • Aberrant DUB expression is common in breast cancer, with some DUBs promoting and others suppressing tumor growth.
  • DUBs influence critical pathways like gene transcription and DNA damage signaling.
  • Specific DUBs, including those in the USP and OTU families, are significantly associated with breast cancer development and progression.

Conclusions:

  • Deubiquitinases represent promising therapeutic targets for overcoming drug resistance in advanced breast cancer.
  • Further research into DUBs' functions and substrates is crucial for developing novel BC treatments.
  • Targeting specific DUB families like USP and OTU may offer new strategies for breast cancer therapy.
Keywords:
Breast cancerDUBDeubiquitinationUbiquitination

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