A novel molecularly imprinted sensor based on MOF-on-MOF architecture and Au nanoparticles for high-sensitivity
Xin Zhang1, Shuang Han2,3, Yuan Wang4
1College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 161006, China.
Abstract:
A novel metal-organic framework (MOF) supported Au nanoparticles (AuNPs)-based molecular imprinted electrochemical sensor (Au-MIECS) has been designed specifically for the detection of metformin (MET). Coupling different MOFs to form MOF-on-MOF structures can provide atomic charge transport channels, promote directional charge transfer and enhance electrochemical performance. To our knowledge, a combination of MOF-on-MOF and MIECS has not been reported. This is the first report on the preparation of MIECS based on MOF-on-MOF architecture. The synergistic effect of high electrical conductivity of AuNPs and the specificity of imprinting sites achieved excellent recognition to MET . The designed ultra-sensitive electrochemical sensor showed rapid response, excellent selectivity and wide linear range of 0.005-80 μM with a low detection limit of 1.911 nM.
