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Updated: Jan 12, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
WT1 gene: a potential therapeutic target for multiple cancer treatment strategies
Tetsuyuki Hirahata1, Reeshan Ul Quraish2, Afraz Ul Quraish1
1Hirahata Gene Therapy Laboratory, HIC Clinic #1105. Itocia Office Tower 11F, 2-7-1. Yurakucho, Chiyoda-Ku, Tokyo, 100-0006, Japan.
Abstract:
The Wilms' Tumor 1 (WT1) gene has attracted significant attention in oncological research owing to its involvement in the pathogenesis of a variety of malignancies. Initially identified in association with Wilms' tumor, a pediatric renal carcinoma, WT1 is now recognized for its broader implications in the etiology of multiple cancers, including leukemia, ovarian cancer, and lung cancer. This review offers a comprehensive analysis of the historical development of WT1 research, explores its mechanisms in cancer progression, and assesses its potential as a therapeutic target, with an emphasis on its clinical implications for cancer treatment strategies.
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